Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. Biochem Soc Trans 1993;21 ( Pt 3)(3):314S. Alpha-lipoic acid is a natural protective antioxidant. This may be how lipoic acid helps to combat obesity and diabetes [, Because of its antioxidant properties, lipoic acid may act as a neuroprotective agent. Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Neurology 1998;50(3):645-651. Lu YH. Namazi N, Larijani B, Azadbakht L. Alpha-lipoic acid supplement in obesity treatment: a systematic review and meta-analysis of clinical trials. But early research shows that alpha-lipoic acid doesn't seem to improve body weight in children who are overweight or obese. Taken internally, alpha lipoic acid is a water- and fat-soluble antioxidant capable of regenerating other antioxidants, such as vitamins C and E. It â¦ The authors concluded that ALA could be a helpful addition to a weight loss program, but that ALA by itself won’t trigger weight loss . However, much more clinical testing is needed before a definitive conclusion about the efficacy of Alpha Lipoic Acid can be reached. We conducted a randomized, double-blind, placebo-controlled clinical trial in 20 adults diagnosed with idiopathic CTS after clinical and neurophysiologic assessment. Huang Z, Wan X, Liu J, et al. Alpha lipoic acid was given in supplements that also contained vitamin C, vitamin E, and polyunsaturated fatty acids for 2 months before and 6 months after phototherapy. Leong J. Y., van der Merwe J., Pepe S., Bailey M., Perkins A., Lymbury R., Esmore D., Marasco S., Rosenfeldt F. Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomised trial. Altern.Med Rev. J Clin Pharmacol 2003;43(11):1257-1267. Diabet Med 1999;16:1040-3. Am J Physiol Heart Circ.Physiol 2009;297(5):H1870-H1875. Spisakova, M., Cizek, Z., and Melkova, Z. Ethacrynic and alpha-lipoic acids inhibit vaccinia virus late gene expression. Alpha-lipoic acid may cause skin issues. Mushroom poisoning. Du X., Edelstein D., Brownlee M. Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. Effects of lipoic acid on diabetic peripheral neuropathy. Biochem.Pharmacol. Effect of lipoic acid in patient with defective activity of pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase, and branched-chain keto acid dehydrogenase. View abstract. SelfDecode provides recommendations that are personalized based on YOUR genes to help you stay healthy and avoid infections from viruses like COVID-19! Zhou L. Effects of cilostazol and -lipoic acid on diabetic peripheral neuropathy. If you are allergic to alpha-lipoic acid; any part of alpha-lipoic acid; or any other drugs, foods, or substances. In various parts of Europe, high dosage supplements with alpha-lipoic acid have been used for a range of different conditions, including neuropathy. View abstract. Eur J Appl.Physiol 2009;107(4):445-453. Diabetes Technol.Ther 2012;14(3):257-263. View abstract. Korkina L. G., Afanas'ef I. Zhang XL, Feng YL Zhou BA & Wei GY. Lipoic acid can improve blood vessel function by decreasing oxygen-derived free radicals . Ranieri M., Sciuscio M., Cortese A. M., Santamato A., Di Teo L., Ianieri G., Bellomo R. G., Stasi M., Megna M. The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life. Objective: Although many studies have considered alpha-lipoic acid (ALA) as a potent antioxidant with anti-inflammatory functions in oxidative stress-associated inflammatory diseases, few studies have evaluated its efficacy in rheumatoid arthritis (RA).